CONTROL OF GENE EXPRESSION USING A COMPLEX OF AN OLIGONUCLEOTIDE AND A REGULATORY PEPTIDE
摘要
A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
申请公布号
CA2474216(C)
申请公布日期
2012.03.13
申请号
CA20022474216
申请日期
2002.10.11
申请人
IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人
HART, STEPHEN;ALI, SIMAK;PUFONG, BORIS TUMI;PORTER, ANDREW CHRISTOPHER GEORGE;BULUWELA, LAKI;VAINIKKA, SATU;JENKINSON, JOHN DAVID;KANDA, PATRICK