BENZAZOLE DERIVATIVE, COMPOSITION, AND METHOD OF USE AS &bgr;-SECRETASE INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease.

SOLUTION: There is provided a compound selected from the group consisting of 1-methyl-1H-imidazol-3-carboxylic acid[7-(1H-indazole-2-ylcarbamoyl)-1H-benzimidazol-2-yl]-amide, isoquinoline-3-carboxylic acid [4-(4,5,6,7-tetrahydro-1H-benzoimidazol-2-ylcarbamoyl)-1H-benzimidazol-2-yl]-amide, and 2-[(6-cyclopropylethynyl-pyridine-2-carbonyl)-amino]-1H-benzoimidazole-4-carboxylic acid (1H-imidazol-2-yl)-amide, and pharmaceutically acceptable salt thereof.

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