| 发明名称 |
METABOLIC INHIBITOR AGAINST TUMORS HAVING AN IDH MUTATION |
| 摘要 |
<p>Methods for treating a cancer having a mutant isocitrate dehydrogenase (IDH), including, but not limited to, a malignant low-grade glioma, a secondary glioblastoma, a transforming myeloproliferative disorder (tMPD), and an acute myelogenous leukemia (AML), with a glutaminase inhibitor, including, bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), are disclosed.</p> |
| 申请公布号 |
WO2011143160(A9) |
申请公布日期 |
2012.03.08 |
| 申请号 |
WO2011US35841 |
申请日期 |
2011.05.10 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY;RIGGINS, GREGORY JOSEPH;SELTZER, MEGHAN JOYCE;TSUKAMOTO, TAKASHI;DANG, CHI VAN;EMADI, ASHKAN |
发明人 |
RIGGINS, GREGORY JOSEPH;SELTZER, MEGHAN JOYCE;TSUKAMOTO, TAKASHI;DANG, CHI VAN;EMADI, ASHKAN |
| 分类号 |
A61K31/433;A61P35/00 |
主分类号 |
A61K31/433 |
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