发明名称 LATENT HUMAN IMMUNODEFICIENCY VIRUS REACTIVATION
摘要 Provided herein are methods or reactivating a latent Human Immunodeficiency Virus (HIV) infection in a cell. The methods comprise modulating a level of NF-?B activity in the cell by contacting the cell with an agent that produces a transient first increase in the level of NF-?B activity without a second delayed increase in NF-?B activity. Optionally, a second agent is used to prime the reactivation. Also provided herein is an isolated Massilia bacterium or population thereof capable of producing a HIV-1 reactivating factor (HRF). Also provided are methods of culturing the Massilia bacteria. Further provided are methods of reactivating a latent Human Immunodeficiency Virus-1 (HIV-1) infection in a subject comprising administering to the subject a HIV-1 reactivating factor produced by Massilia bacteria, optionally with a priming agent.
申请公布号 WO2011146612(A3) 申请公布日期 2012.03.08
申请号 WO2011US36992 申请日期 2011.05.18
申请人 THE UAB RESEARCH FOUNDATION;KUTSCH, OLAF;NIEDERWEIS, MICHAEL;WOLSCHENDORF, FRANK;DUVERGER, ALEXANDRA;WAGNER, FREDERIC 发明人 KUTSCH, OLAF;NIEDERWEIS, MICHAEL;WOLSCHENDORF, FRANK;DUVERGER, ALEXANDRA;WAGNER, FREDERIC
分类号 A61K39/395;A61P31/00;A61P31/18 主分类号 A61K39/395
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