Provided herein are methods or reactivating a latent Human Immunodeficiency Virus (HIV) infection in a cell. The methods comprise modulating a level of NF-?B activity in the cell by contacting the cell with an agent that produces a transient first increase in the level of NF-?B activity without a second delayed increase in NF-?B activity. Optionally, a second agent is used to prime the reactivation. Also provided herein is an isolated Massilia bacterium or population thereof capable of producing a HIV-1 reactivating factor (HRF). Also provided are methods of culturing the Massilia bacteria. Further provided are methods of reactivating a latent Human Immunodeficiency Virus-1 (HIV-1) infection in a subject comprising administering to the subject a HIV-1 reactivating factor produced by Massilia bacteria, optionally with a priming agent.
申请公布号
WO2011146612(A3)
申请公布日期
2012.03.08
申请号
WO2011US36992
申请日期
2011.05.18
申请人
THE UAB RESEARCH FOUNDATION;KUTSCH, OLAF;NIEDERWEIS, MICHAEL;WOLSCHENDORF, FRANK;DUVERGER, ALEXANDRA;WAGNER, FREDERIC