发明名称 |
ISOLATED HIGH AFFINITY ENTITIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES OF MHC CLASS II AND GLUTAMIC ACID DECARBOXYLASE (GAD) AUTOANTIGENIC PEPTIDES |
摘要 |
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated GAD autoantigenic peptide. Also provided are isolated high affinity entities comprising an antigen binding domain capable of specifically binding a complex composed of a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated GAD autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes. |
申请公布号 |
WO2012007951(A8) |
申请公布日期 |
2012.03.08 |
申请号 |
WO2011IL00564 |
申请日期 |
2011.07.14 |
申请人 |
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.;REITER, YORAM;DAHAN, RONY |
发明人 |
REITER, YORAM;DAHAN, RONY |
分类号 |
C12N15/62;C07K16/28;C07K16/40 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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