The present invention relates to a device for continuous measuring of an analyte which allows monitoring the blood or interstitial glucose level in a minimally invasive, minimally detrimental and painless manner for which it basically comprises a fixed element (1 ) on which there is fixed a disposable and exchangeable element (2) incorporating an automated multi-puncturing system programmable over time comprising a plurality of puncturing units each formed by a micro-needle (3), means for driving said micro-needle (3), an elastic spring (10) returning it to its resting state and a biosensor wherein the glucose data which is subsequently transmitted to an external reading and management device is extracted.