摘要 |
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2′-position of the ribose rings and/or the terminal 3′- and/or 5′-positions of the oligonucleotide; 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide. |
申请人 |
MERCK SHARP & DOHME CORP.;COLLETTI, STEVEN, L.;GOSSELIN, FRANCIS;JADHAV, VASANT, R.;SHAW, ANTHONY, W.;TELLERS, DAVID, M.;TUCKER, THOMAS, J.;YUAN, YU;ZEWGE, DANIEL |
发明人 |
COLLETTI, STEVEN, L.;GOSSELIN, FRANCIS;JADHAV, VASANT, R.;SHAW, ANTHONY, W.;TELLERS, DAVID, M.;TUCKER, THOMAS, J.;YUAN, YU;ZEWGE, DANIEL |