IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME

摘要

Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanopart icles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. [Relation 1] 5 = 100* Dm(I0)/ Cv(I0) [Relation 2] 2.5 = 100* Dm(Cap)/ Cv(Cap) [Relation 3] 0.5 wt% m(I0) m(Cap) = 200 nm.