发明名称 NLK AS A MARKER FOR DIAGNOSIS OF LIVER CANCER AND AS A THERAPEUTIC AGENT THEREOF
摘要 <p>The present invention relates to a novel marker for the diagnosis of liver cancer and the use thereof. More specifically, the present invention relates to a marker for the diagnosis of liver cancer, using NLK (nemo like kinase) by confirming the overexpression of the NLK in the liver cancer cells, and to a composition, a kit, a microarray, and a method for the diagnosis of liver cancer using the marker. The present invention also relates to a method for screening a substance that can prevent or treat liver cancer by reducing the expression of a marker gene or a protein, and to a composition for preventing or treating liver cancer, which includes said substance. According to the present invention, NLK, which is the marker gene for liver cancer, has an unusually increased amount of expression in the liver cancer tissues compared to the normal liver tissues, and thus suppressing the expression of said gene reduces the expression of cyclin D1 and CDK2 in liver cancer cells, suppresses the progression of a cell cycle in stage G1/S, and at the same time, restrains the proliferation of the cells, thereby effectively preventing or treating liver cancer. Therefore, the NLK gene discovered in the current invention can be usefully used as a target for the diagnosis and the treatment of liver cancer.</p>
申请公布号 WO2011118994(A9) 申请公布日期 2012.03.08
申请号 WO2011KR02031 申请日期 2011.03.25
申请人 CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION;NAM, SUK WOO 发明人 NAM, SUK WOO
分类号 C12Q1/68;A61K48/00;A61P35/00;C12N15/113;G01N33/574 主分类号 C12Q1/68
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