发明名称 |
ANTIBODY GEL SYSTEM FOR SUSTAINED DRUG DELIVERY |
摘要 |
<p>Antibody formulations, and methods for their manufacture, which (i) are capable of preserving an antibody in a native and therapeutically active state while achieving a depot effect without the use of polymers or other complex formulation reagents and (ii) provide very high loading capacity, thus offering the potential for increased dose per application to patient. These formulations take the form of a gel and are based on the surprising finding that some monoclonal antibodies have a gelation property under appropriate conditions.</p> |
申请公布号 |
WO2012028683(A1) |
申请公布日期 |
2012.03.08 |
申请号 |
WO2011EP65096 |
申请日期 |
2011.09.01 |
申请人 |
NOVARTIS AG;RODRIGUES, MARGARIDA;SCHOENHAMMER, KARIN |
发明人 |
RODRIGUES, MARGARIDA;SCHOENHAMMER, KARIN |
分类号 |
A61K9/19;A61K9/00;C07K16/18;C07K16/22 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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