| 摘要 |
<p>The purpose of the present invention is to provide a novel therapeutic agent for IMPA2-related peripheral diseases including obesity and diabetes and a method for screening for such a therapeutic agent. A compound of the present invention, which inhibits the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, 3, 5, 7, 9 or 11, or a salt and the like of the compound can be used as a prophylactic or therapeutic agent for IMPA2-related peripheral diseases such as diseases associated with intracellular accumulation of triglycerides (for example, obesity, diabetes, hyperlipemia, arteriosclerosis, chronic nephropathy, diabetic nephropathy, fatty liver, hypertension, ischemic heart disease and cancer) and diseases associated with intracellular mitochondrial activity (for example, obesity, retinal degenerative disease, diabetic neuropathy, diabetic retinopathy, renal glomerular sclerosis, nephropathy, diabetic nephropathy, chronic nephropathy, insulin resistance disease, hypertension, arteriosclerosis, diabetes, oxidative stress, ischemic heart disease, aging, muscle disorder, nerve disorder, hearing loss, blindness, fatty liver, steatohepatitis, viral hepatitis, biliary liver cirrhosis, ischemia reperfusion injury, graft rejection, hemolytic anemia and cancer).</p> |
