| 发明名称 |
IL-17 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF |
| 摘要 |
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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| 申请公布号 |
US2012058909(A1) |
申请公布日期 |
2012.03.08 |
| 申请号 |
US201113269984 |
申请日期 |
2011.10.10 |
| 申请人 |
CHEN JIAN;FILVAROFF ELLERI;FONG SHERMAN;FRENCH DOROTHY;GODDARD AUDREY;GODOWSKI PAUL J.;GRIMALDI J. CHRISTOPHER;GURNEY AUSTIN L.;HILIAN KENNETH J.;HYMOWITZ SARAH G.;LI HANZHONG;PAN JAMES;STAROVASNIK MELISSA A.;TUMAS DANIEL;LOOKEREN MENNO VAN;VANDLEN RICHARD;WATANABE COLIN K.;WILLIAMS P. MICKEY;WOOD WILLIAM I.;YANSURA DANIEL G. |
发明人 |
CHEN JIAN;FILVAROFF ELLERI;FONG SHERMAN;FRENCH DOROTHY;GODDARD AUDREY;GODOWSKI PAUL J.;GRIMALDI J. CHRISTOPHER;GURNEY AUSTIN L.;HILIAN KENNETH J.;HYMOWITZ SARAH G.;LI HANZHONG;PAN JAMES;STAROVASNIK MELISSA A.;TUMAS DANIEL;LOOKEREN MENNO VAN;VANDLEN RICHARD;WATANABE COLIN K.;WILLIAMS P. MICKEY;WOOD WILLIAM I.;YANSURA DANIEL G. |
| 分类号 |
C40B30/04;C07H21/04;C07K14/715;C12N5/06;C12P21/02;C12Q1/68;G01N33/574 |
主分类号 |
C40B30/04 |
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