发明名称 |
HUMAN FGF RECEPTOR AND ß-KLOTHO BINDING PROTEINS |
摘要 |
The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to ß-Klotho, or ß-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to ß-Klotho, or ß-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions. |
申请公布号 |
WO2011130417(A3) |
申请公布日期 |
2012.03.08 |
申请号 |
WO2011US32333 |
申请日期 |
2011.04.13 |
申请人 |
AMGEN INC.;FACHINI, ROGER;FOLTZ, IAN;HAN, SEOG JOON;HARRIS, SUSIE MIKI;HU, SHAW-FEN SYLVIA;KING, CHADWICK TERENCE;LI, YANG;LU, JI;MICHAELS, MARK LEO;SUN, JEONGHOON |
发明人 |
FACHINI, ROGER;FOLTZ, IAN;HAN, SEOG JOON;HARRIS, SUSIE MIKI;HU, SHAW-FEN SYLVIA;KING, CHADWICK TERENCE;LI, YANG;LU, JI;MICHAELS, MARK LEO;SUN, JEONGHOON |
分类号 |
C07K16/28;A61K39/395;A61P3/10 |
主分类号 |
C07K16/28 |
代理机构 |
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地址 |
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