TREATMENT OF THE ADVERSE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF AN ANTI-HYALURONAN AGENT
摘要
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
申请公布号
WO2012012300(A3)
申请公布日期
2012.03.08
申请号
WO2011US44281
申请日期
2011.07.15
申请人
HALOZYME, INC.;SHEPARD, HAROLD, MICHAEL;THOMPSON, CURTIS;LI, XIAOMING;FROST, GREGORY, IAN
发明人
SHEPARD, HAROLD, MICHAEL;THOMPSON, CURTIS;LI, XIAOMING;FROST, GREGORY, IAN