COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
摘要
<p>Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.</p>
申请公布号
EP2296653(A4)
申请公布日期
2012.03.07
申请号
EP20090759347
申请日期
2009.06.03
申请人
INTERMUNE, INC.
发明人
KOSSEN, KARL;SEIWERT, SCOTT, D.;SEREBRYANY, VLADIMIR;RUHRMUND, DONALD;BEIGELMAN, LEONID;RAVEGLIA, LUCA, FRANCESCO MARIO;VALLESE, STEFANIA;BIANCHI, IVANA;HU, TAO