发明名称 |
METHOD FOR MAKING HETEROMULTIMERIC MOLECULES |
摘要 |
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered. |
申请公布号 |
EP2424567(A2) |
申请公布日期 |
2012.03.07 |
申请号 |
EP20100772544 |
申请日期 |
2010.04.27 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN, L.;SATO, AARON, KEN |
分类号 |
C12P21/08 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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