发明名称 |
PROCESS FOR THE PREPARATION OF IBODUTANT (MEN15596) AND RELATED INTERMEDIATES. |
摘要 |
<p>This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of high- yield steps involving reagents and solvents with low environmental impact, characterised by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesised by coupling of 6-methyl-2- benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalisations of 4-aminomethylpiperidine (2).</p> |
申请公布号 |
MX2011012317(A) |
申请公布日期 |
2012.03.07 |
申请号 |
MX20110012317 |
申请日期 |
2010.05.11 |
申请人 |
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. |
发明人 |
BONACCORSI, FABRIZIO;FEDI, VALENTINA;GIANNOTTI, DANILO |
分类号 |
C07D409/12;A61K38/05;A61P25/00 |
主分类号 |
C07D409/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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