发明名称 |
Conjugates of biologically active proteins having a modified in vivo half-life |
摘要 |
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide. |
申请公布号 |
US8129348(B2) |
申请公布日期 |
2012.03.06 |
申请号 |
US20080251324 |
申请日期 |
2008.10.14 |
申请人 |
BESMAN MARC;CHIPMAN STEWART;LEUNG DAVID;SINGER JACK;CELL THERAPEUTICS, INC. |
发明人 |
BESMAN MARC;CHIPMAN STEWART;LEUNG DAVID;SINGER JACK |
分类号 |
A61K38/16;A61K38/14;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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