发明名称 |
LIPOIC ACID DERIVATIVES AND THEIR USE IN TREATMENT OF DISEASE |
摘要 |
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.
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申请公布号 |
CA2348998(C) |
申请公布日期 |
2012.03.06 |
申请号 |
CA19992348998 |
申请日期 |
1999.10.26 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
BINGHAM, PAUL M.;ZACHAR, ZUZANA |
分类号 |
A61K31/381;C07D339/04;A61K31/19;A61K31/192;A61K31/265;A61K31/28;A61K31/282;A61K31/325;A61K31/385;A61K31/40;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07C311/49;C07C323/52;C07C327/32;C07F19/00 |
主分类号 |
A61K31/381 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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