| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide immunosuppressive agents for treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases. <P>SOLUTION: Compounds represented by formula (I), wherein R<SB POS="POST">1</SB>, R<SB POS="POST">2</SB>and R<SB POS="POST">3</SB>are defined in the specification, are inhibitors of the enzyme protein tyrosine kinase, such as Janus Kinase 3, and as such are useful therapy as immunosuppressive agents for organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases. <P>COPYRIGHT: (C)2012,JPO&INPIT |
