| 发明名称 |
Peptide epoxyketones for proteasome inhibition |
| 摘要 |
<p>Abstract One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain 5 embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.</p> |
| 申请公布号 |
AU2012200797(A1) |
申请公布日期 |
2012.03.01 |
| 申请号 |
AU20120200797 |
申请日期 |
2012.02.10 |
| 申请人 |
PROTEOLIX, INC. |
发明人 |
SHENK, KEVIN D.;PARLATI, FRANCESCO;ZHOU, HAN-JIE;SYLVAIN, CATHERINE;SMYTH, MARK S. |
| 分类号 |
C07D303/32;A61K31/336;A61K31/404;A61K38/05;A61P35/00;A61P37/00;C07D405/12;C07D409/12;C07K5/062;C07K5/065;C07K5/068;C07K5/072;C07K5/078 |
主分类号 |
C07D303/32 |
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