FUSION POLYPEPTIDE CAPABLE OF ACTIVATING RECEPTOR

摘要

PROBLEM TO BE SOLVED: To provide multimeric fusion polypeptides capable of activating a target receptor requiring multimerization to be activated.

SOLUTION: The fusion polypeptide comprises (A)x-M-(A')y, wherein A and A' are each polypeptides capable of binding the target receptor. The fusion polypeptides form multimeric proteins which activate the target receptor. A and A' may be each an antibody or fragment derived from an antibody specific for the target receptor, such as the same or different ScFv fragments, and/or a ligand or ligand fragment or derivative capable of binding a target protein. M is a multimerizing component, and x and y are independently a number between 1-10.

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