| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions containing lipase for the treatment of disorders characterized by low lipase secretion. <P>SOLUTION: The compositions includes crosslinked lipase crystals that are highly resistant to proteolysis, low pH, and elevated temperature. The invention is based in part on the discovery of compositions which include lipase in a crosslinked crystalline form that is highly resistant to proteolytic and acid degradation. Because the crosslinked crystalline lipase exhibits high stability against proteases and acid, the composition can be administered in low doses to patients suffering from gastrointestinal disorders. In one aspect, the invention provides a composition that includes a crosslinked lipase crystal, a protease, and an amylase. The lipase crystal in the composition is crosslinked with a multifunctional crosslinking agent and is preferably stable at pH 1-9. Preferably, the enzyme is active at a pH range from about 2.0 to 9.0. More preferably, the enzyme is active at pH 4-7. <P>COPYRIGHT: (C)2012,JPO&INPIT |
