| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a series of N-substituted diazabicyclic compound, a method for selectively controlling releasing of a synaptic transmission substance in mammals by using the compound, and a pharmaceutical composition including the compound. <P>SOLUTION: The present invention provides a compound expressed by formula (I), a pharmaceutical composition of the compound, and use of the composition to control synaptic transmission in mammals (in a nicotinic acetylcholine receptor ligand). In formula (I), A is selected from a group consisting of CH2, CH2CH2, and the like; B is selected from a group consisting of CH2 and CH2CH2, however, when A is CH2CH2CH2, B is CH2; Y is selected from a group consisting of CH2 and CH2CH2; Z is selected from a group consisting of CH2 and CH2CH2, however, when Y is CH2CH2, Z is a covalent bond, and when Z is CH2CH2, Y is a covalent bond; and Rl is pyridine or the like. <P>COPYRIGHT: (C)2012,JPO&INPIT |
