发明名称 |
METHODS AND SYSTEMS FOR PROLONGED LOCALIZATION OF DRUG DELIVERY |
摘要 |
An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.
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申请公布号 |
US2012053451(A1) |
申请公布日期 |
2012.03.01 |
申请号 |
US201113217883 |
申请日期 |
2011.08.25 |
申请人 |
LAULICHT BRYAN;MATHIOWITZ EDITH;BROWN UNIVERSITY |
发明人 |
LAULICHT BRYAN;MATHIOWITZ EDITH |
分类号 |
A61B5/05;A61K9/19;A61P1/04;A61P3/10;A61P7/10;A61P11/00;A61P11/08;A61P23/00;A61P31/00;A61P37/06;A61P39/00;H01F1/00 |
主分类号 |
A61B5/05 |
代理机构 |
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代理人 |
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地址 |
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