发明名称 USE OF THE ASSOCIATION OF A SINUS NODE IF CURRENT INHIBITOR AND AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR IN THE TREATMENT OF HEART FAILURE
摘要 Combination (I) comprises a selective and specific sinusal I f(mixed sodium ion-potassium ion inward current) current inhibitor (A) and an angiotensin converting enzyme inhibitor (B). An independent claim is included for pharmaceutical compositions comprising: ivabradine, in the form of hydrochloride or its hydrate or crystalline forms, and perindopril, in the form of salt of tert-butylamine or arginine or their hydrates or crystalline forms, alone or in combination with one or more excipient. ACTIVITY : Cardiant; Cardiovascular-Gen.; Vasotropic; Antianginal; Antiarrhythmic. MECHANISM OF ACTION : Sinusal I fcurrent inhibitor; Angiotensin converting enzyme inhibitor.
申请公布号 ZA201104222(B) 申请公布日期 2012.02.29
申请号 ZA20110004222 申请日期 2011.06.07
申请人 LES LABORATORIES SERVIER 发明人 THUILLEZ CHRISTIAN;MULDER PAULUS;VILAINE JEAN-PAUL;FRATACCI MARIE-DOMINIQUE;LEREBOURS-PIGEONNIERE GUY;FELDMANN LUC;ROUSSEL JEROME
分类号 A61K;A61P;C07D 主分类号 A61K
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