PROCESS FOR PRODUCING CHROMANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

4-Heterocyclyl-chroman derivs. of formula (I) and their salts are new. In (I), R1=A; R2=H or A, or R1 and R2 are together 3-6C alkylene; R3=OH or OAc; R4=H, or R3 and R4 are together a bond; R5=1H-2-pyridon-1-yl; 1H-2-pyrimidinon-1-yl; 1H-6-pyrimidinon-1-yl; 1H-2-pyrazinon-1-yl or 1H-2-thiopyridon-1-yl, all opt. partially hydrogenated and/or substd. by 1 or 2 of A, F, Cl, Br, I, OH, OA, OAc, NO2, NH2, NHAc, COOH and COOA; R6 and R7=H, A, HO, AO, CHO, ACO, ACS, COOH, COOA, CSOA, ACOO, ACSO, 1-6C hydroxyalkyl or mercaptoalkyl, NO2, NH2, NHA, NA2, CN, F, Cl, F, Cl, Br, I, CF3, ASO, ASO2, AOSO, AOSO2, AcNH, AO.CO.NH, NH2SO, HNA.SO, A2NSO, NH2SO2, HNA.SO2, A2NSO2, NH2CO, HNA.CO, N2A.CO, NH2CS, HNA.CS, A2NCS, A.SONH, A.SO2NH, AOSO.NH, AOSO2NH, ACO-alk, nitro-alk, cyano-alk, A=C(=NOH) or A-C(=NNH2); A=1-6C alkyl; alk=1-6C alkylene; Ac= 1-8C alkanoyl or 7-11C aroyl. - Specifically claimed are 7 cpds. e.g. a cpd. of formula (i), where Q1=CN or NO2, and Q2=1H-2-pyridon-1-yl; Q1=CN, and Q2=1H-2-pyrazinon-1-yl.