METHODS FOR MATURING PRECURSOR B CELLS

摘要

The present invention provides for a method of inducing differentiation of precursor B cells to immunoglobulin (Ig)-secreting cells comprising contacting said precursor B cells with an aqueous medium comprised of IL-4 and a contact mediated signal provided by optimally activated CD4+ cells. The present invention further provides for a method of inducing differentiation of precursor B cells to immunoglobulin (Ig)-secreting cells comprising contacting said percursor B cells with an aqueous medium comprised of IL-4, IL-7 and a contact mediated signal provided by non-optimally activated CD4+ cells.