发明名称 |
PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER. |
摘要 |
<p>The present invention relates to a combination for the treatment of cancer wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin dependent kinase (CDK) inhibitor selected from the compounds of formula I or a pharmaceutically acceptable salt or a solvate thereof. The present invention also relates to a method for the treatment of cancer, which method comprises administering to a patient in need of such a treatment, a therapeutically effective amount of the combination. The present invention also relates to the use of a CDK inhibitor selected from the compounds of formula I as a radiosensitizer that enhances the efficacy of radiotherapy for the treatment of cancer, particularly head and neck cancer.</p> |
申请公布号 |
MX2011011687(A) |
申请公布日期 |
2012.02.29 |
申请号 |
MX20110011687 |
申请日期 |
2010.05.03 |
申请人 |
PIRAMAL LIFE SCIENCES LIMITED |
发明人 |
SHARMA, SOMESH;RATHOS, MAGGIE JOYCE;JOSHI, KALPANA SANJAY;HEBBAR, NIKHIL KRISHNAMURTHY |
分类号 |
A61K31/4025;A61K31/00;A61P35/02 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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