发明名称 |
INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF 4- (ACETYLAMINO) ) -3- [ (4-CHLORO-PHENYL) THIO] -2-METHYL-1H-INDOLE-1-ACETIC ACID |
摘要 |
<p>The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound of formula (I): X is =0, =N-0H or =N-OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or -CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.</p> |
申请公布号 |
SG177286(A1) |
申请公布日期 |
2012.02.28 |
申请号 |
SG20110094166 |
申请日期 |
2010.07.05 |
申请人 |
ASTRAZENECA AB |
发明人 |
AINGE, DEBRA;BUTTERS, MICHAEL;MERIFIELD, ERIC;RAMAKRISHNAN, RAVI;RAYAPATI, RAVI NAIDU;SHARMA, PARHALAD RAY;THOMSON, COLIN |
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