| 摘要 |
PURPOSE: A manufacturing method of 4-hydroxy-3-methoxyphenyl-2-propenone derivatives is provided to obtain 4-hydroxy-3-methoxyphenyl-2-propenone derivatives with high purity and high yield under mild reaction condition. CONSTITUTION: A compound or pharmaceutically acceptable salts thereof are in chemical formula 1, 2, or 3. A manufacturing method of the compound comprises a step of reacting a compound in chemical formula 4, and 1,3-diacetylbenzene, or 1,3,5-triacetylbenzene under the presence of acid. In chemical formulas R1 and R2 is respectively and independently selected from a group consisting of hydrogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, trimethylsilyl, and C1-6 alkylcarbonyl.
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