发明名称 |
MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO |
摘要 |
<p>The purpose of the present invention is to provide a motilin-like peptide compound which maintains the digestive tract motor-stimulating activity of motilin and to which a high absorbability in transmucosal administration is imparted.For this purpose, motilin derivatives are designed and synthesized while considering the degradation passage of motilin at a transmucosal absorption site and the maintenance of the physiological activity of motilin. As a result, it is confirmed that a compound, which is characterized by having an amino acid substitution at the 21-position of natural motilin, shows a high absorbability in transmucosal administration and maintains the same activity as motilin. Thus, the present invention has been completed.</p> |
申请公布号 |
SG177592(A1) |
申请公布日期 |
2012.02.28 |
申请号 |
SG20120001715 |
申请日期 |
2010.07.29 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
SATO, SEIJI;HANADA, TAKESHI;WAKABAYASHI, NAOMI;MASUDA, YUTAKA;HARADA, YURIKO |
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