发明名称 |
Crystal structure of aldehyde dehydrogenase and methods of use thereof |
摘要 |
The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates. |
申请公布号 |
US8124389(B2) |
申请公布日期 |
2012.02.28 |
申请号 |
US20090435265 |
申请日期 |
2009.05.04 |
申请人 |
CHEN CHE-HONG;MOCHLY-ROSEN DARIA;HURLEY THOMAS D.;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
CHEN CHE-HONG;MOCHLY-ROSEN DARIA;HURLEY THOMAS D. |
分类号 |
C12N9/04 |
主分类号 |
C12N9/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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