| 发明名称 |
DIAGNOSTIC METHOD FOR PREDICTING THE RISK OF CANCER RECURRENCE BASED ON HISTONE MACROH2A ISOFORMS |
| 摘要 |
<p>The present invention relates to a method for diagnosing the risk of cancer recurrence in a mammalian patient, comprising detecting the expression of macroH2A1.1 and/or macroH2A2 in a biological sample obtained from said patient, wherein a low or reduced expression of said macroH2A1.1 and/or macroH2A2 is indicative for an increased risk of cancer recurrence in said patient. The present invention is further directed at improved methods for treating cancer, in particular breast and/or lung cancer, based on said diagnostic method.</p> |
| 申请公布号 |
SG177398(A1) |
申请公布日期 |
2012.02.28 |
| 申请号 |
SG20110096849 |
申请日期 |
2010.07.02 |
| 申请人 |
EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORY;THORAXKLINIK-HEIDELBERG GGMBH |
发明人 |
LADURNER, ANDREAS;SPORN, JUDITH;MULEY, THOMAS |
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