发明名称 AGENT HAVING ANTIBACTERIAL ACTIVITY
摘要 FIELD: chemistry. ^ SUBSTANCE: disclosed is an agent which is 1,5-bis-(4-dodecyl-1,4-diazoniabicyclo[2.2.2]octan-1-yl)pentane dichloride dibromide with a structural formula shown on dwg. 1, which can be used to treat viral diseases of animals (e.g., bovine virus diarrhoea), accompanied by bacterial infections. Synthesis of the disclosed compound takes place in methanol as a solvent in 20-24 hours with molar ratio of the following components: 1-dodecyl-4-aza-1-azoniabicyclo[2.2.2]octane chloride to 1,5-dibromopentane equal to 1:(2.0-2.16), with 80.4-83.7% output of the end product. ^ EFFECT: agent has low toxicity, is stable during storage at room temperature for 3 years, has marked antibacterial action on pathogenic strains of microorganisms. ^ 1 cl, 2 dwg, 3 tbl, 6 ex
申请公布号 RU2443705(C1) 申请公布日期 2012.02.27
申请号 RU20100148444 申请日期 2010.11.26
申请人 UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT KHIMICHESKOJ BIOLOGII I FUNDAMENTAL'NOJ MEDITSINY SIBIRSKOGO OTDELENIJA RAN (IKHBFM SO RAN) 发明人 SIL'NIKOV VLADIMIR NIKOLAEVICH;BURAKOVA EKATERINA ANATOL'EVNA;GLOTOVA TAT'JANA IVANOVNA;GLOTOV ALEKSANDR GAVRILOVICH;REPIN VLADIMIR EVGEN'EVICH
分类号 A61K31/4995;A61P31/04;A61P31/12;C07D487/08 主分类号 A61K31/4995
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