摘要 |
A compound of formula I e.g. N-(2-(2-chlorophenyl)-S,6-dimethylpyrimidin-4-yl)-S-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine or a pharmaceutically acceptable salt thereof, wherein: RX is alkyl and RY is alkyl for treating or lessening the severity of a disease or condition selected from diabetes, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), schizophrenia, leukocytopenia, stroke, and rheumatoid arthritis, stroke, spinal cord injury, traumatic brain injury, Charcot-Marie- Tooth, and diabetic neuropathy.
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申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
PIERCE, ALBERT;COME, JON;COURT, JOHN;GAO, HUAI;HENKEL, GREGORY;LIU, MICHAEL;NEUBERGER, TIMOTHY |