PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER

摘要

Disclosed is a tetrahydropteridine compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: Cyclopentyl4-[(4-{ [(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino} -3-methoxybenzoyl)amino]-L-phenylalaninate, Cyclopentyl O-(4-{ [(4-{ [(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino} -3-methoxybenzoyl)amino]methyl} phenyl)-L-homoserinate and tert-butyl 4-[(4-{ [(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino} -3-methoxybenzoyl)amino]-L-phenylalaninate. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) for the manufacture of a medicament for treating cell proliferation diseases (such as cancer).