RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE

摘要

Disclosed is a nucleic acid molecule that encodes a substantially nontoxic mutein of Clostridium perfringens alpha-toxin. The mutein alpha-toxin comprises an amino acid sequence as defined in the complete specification minus at least 9 consecutive amino acid residues; with no more than 48 consecutive amino acid residues deleted; and wherein one of the deleted amino acid residues is His68.