INDOLES AND THEIR THERAPEUTIC USE

摘要

Disclosed is a compound that is an indole derivative of formula (I), e.g. [3-(4-benzenesulfonylisothiazol-5-ylmethyl)-5-fluoro-2-methylindol-1-yl-acetic acid or a pharmaceutically acceptable salt thereof wherein X, R1, R2, R3 is defined in the specification and Ar1 is furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl and Ar2 is pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl for the treatment of psoriasis, atopic and non-atopic dermatitis, Crohn's disease, ulcerative colitis, or irritable bowel disease.