| 摘要 |
Disclosed is a process for preparing 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H imidazole hydrochloride of formula (V) comprising the steps of: a) condensing the 1-trityl-1H-imidazole-4-carboxaldehyde with phtalide to form 2-(1-trityl-1H-imidazole-4-yl)indan-1,3-dione, b) alkylating the product of step (a) with ethyl iodide to form 2-ethyl-2-(1-trityl-1H-imidazole-4-yl)indan-1,3-dione, c) removing the trityl group from the product of step (b) by acid hydrolysis and form 2-ethyl-2-(1 H-imidazol-4-yl)indan-1,3-dione, d) reducing the product of step (c) by catalytic hydrogenation to form the desired 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H imidazole hydrochloride. Also disclosed are the intermediates 2-(1-Trityl-1H-imidazole-4-yl)indan-1,3-dione and 2-Ethyl-2-( 1-trityl-1H-imidazole-4-yl)indan-1,3-dione.
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