IMMUNOSTIMULATORY COMPOSITIONS COMPRISING LIPOSOME-ENCAPSULATED OLIGONUCLEOTIDES AS ACTIVE INGREDIENTS

摘要

PURPOSE: An immunostimulatory composition containing liposome-encapsulated oligonucleotides including DOPE and CHEMS is provided to treat and prevent diseases relating to immunological deficiency. CONSTITUTION: An immunostimulatory composition contains liposome-encapsulated immunostimulatory oligonucleotides as an active ingredient, including DOPE(dioleyl phosphatidylethanolamine) and CHEMS(cholesterylhemisuccinate). The immunostimulatory oligonucleotide is CpG oligonucleotide or CpT oligonucleotide. The composition contains the CpT oligonucleotide including a nucleotide sequence of general formula 1(CTX1X2CTX3X4X5CT) or 2(CTX1X2X3CTX4X5X6CT).