FUSED, TRICYCLIC ARYL SULFONAMIDO INHIBITORS OF GAMMA SECRETASE, BETA AMYLOID RELEASE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS SUCH AS ALZHEIMER'S

摘要

Disclosed is a compound of formula I or pharmaceutically acceptable salts thereof, potentially in a pharmaceutical composition. Specific examples of the compound include 5-[(4-chlorophenyl)sulfonyl]-8-fluoro-4,5-dihydro-2H-pyrazolo [ 4,3-c]quinoline and 4-(4-cyc1opropyl-1H-pyrazolo[4,3-c]quinolin-5(4H)-ylsulfonyl)benzonitrile. Also disclosed is the use of the compound for treating an A beta-related disease, Alzheimer's disease, mild cognitive impairment, dementia, or Down's syndrome.