Piperidinyl, indolyl, pirinidyl, morpholinyl and benzimidazolyl urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammations and other diseases

摘要

Disclosed is a piperidine compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of the invention are: 1-(1-acetyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea, 1-(1-trifluoromethylcarbonylpiperidin-4-yl)-3 -(4-trifluoromethoxyphenyl)urea and N-(1-methanesulfonylpiperidin-4-yl)-N'-(4-trifluoromethoxyphenyl)urea. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), an in vitro method for inhibiting a soluble epoxide hydrolase and the use of a compound of formula (I) in the manufacture of a medicament for treating a disease modulated by soluble epoxide hydrolases for example hypertension, inflammation, adult respiratory distress syndrome; obstructive pulmonary disease; interstitial lung disease; asthma; diabetic complications; end stage renal disease; renal deterioration; nephropathy; Raynaud syndrome and arthritis. The compounds are also useful for treating conditions responsive to regulation of endothelial cell function.