发明名称 |
CRYSTALLINE FORMS OF TOPOTECAN HYDROCHLORIDE AND PROCESSES FOR MAKING THE SAME |
摘要 |
Disclosed is a crystalline Form D of topotecan hydrochloride characterized by a powder X-ray diffraction pattern having peaks at 5.9, 13.9, 22.6, 23.2 and 26.5 o20 (+0.2o). Further disclosed is a process for preparing the topotecan hydrochloride as described above comprising: (a) dissolving topotecan hydrochloride in a first solvent system; (b) adjusting the pH of the resulting mixture of step (a) to below 1.2; c) adding a volume of low polar solvent into the mixture of step (b) to form a second solvent system, wherein the first solvent system is more polar than the second solvent system; and (d) crystallizing the topotecan hydrochloride Form D from the second solvent system.
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申请公布号 |
NZ580516(A) |
申请公布日期 |
2012.02.24 |
申请号 |
NZ20080580516 |
申请日期 |
2008.04.14 |
申请人 |
SCINOPHARM TAIWAN, LTD. |
发明人 |
HU, TSUNG-CHENG;CHEN, SHU-PING;HARN, PIIN-JYE;SHIEH, CHIA-LIN CHARLENE |
分类号 |
C07D491/22;A61K31/4745 |
主分类号 |
C07D491/22 |
代理机构 |
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主权项 |
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地址 |
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