| 摘要 |
Disclosed is the use of a non-occlusive transdermal drug delivery composition in the manufacture of a medicament for application to at least one axilla (arm pit) of a person, without occlusion by a patch device, for the treatment of testosterone deficiency, the composition comprising: (a) a pharmaceutically effective amount of at least one androgen selected from testosterone and pharmaceutically acceptable salts thereof; (b) a solvent selected from the group consisting of ethanol, isopropanol and mixtures thereof in an amount of at least 60% v/v of the composition; (c) one or more penetration enhancers selected from the group consisting of glycols, oleic acid, isopropyl myristate, cyclopentadecanone, sorbitan monooleate, octyl salicylate, octyl dimethyl-para-aminobenzoate and octyl paramethoxycinnamate; (d) one or more viscosity modulating agents; e) optionally, an activator for the viscosity modulating agent; (f) optionally, an antiperspirant and/or deodorant agent; and (g) optionally, water. |
