发明名称 |
SUBSTITUTED HETEROARYL SPIROPYRROLIDINE MDM2 ANTAGONISTS |
摘要 |
<p>There are provided compounds of the general formula (I) wherein A, B, V, W, R1, R2, R3, R3, and R4, are as described herein, enantiomers and pharmaceutically acceptable salts thereof, as well as methods for making said compounds and pharmaceutical compositions containing them. The present compounds are useful as anticancer agents, in particular as agents in the therapeutic and/or prophylactic treatment of solid tumors such as for example breast, colon, lung and prostate tumors.</p> |
申请公布号 |
WO2012022707(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
WO2011EP64015 |
申请日期 |
2011.08.15 |
申请人 |
F. HOFFMANN-LA ROCHE AG;BARTKOVITZ, DAVID JOSEPH;CHU, XIN-JIE;DING, QINGJIE;KARNACHI, PRABHA SABA;LIU, JIN-JUN;SO, SUNG-SAU;ZHANG, JING;ZHANG, ZHUMING |
发明人 |
BARTKOVITZ, DAVID JOSEPH;CHU, XIN-JIE;DING, QINGJIE;KARNACHI, PRABHA SABA;LIU, JIN-JUN;SO, SUNG-SAU;ZHANG, JING;ZHANG, ZHUMING |
分类号 |
C07D471/10;A61K31/407;A61K31/437;A61K31/519;A61P35/00;C07D487/10;C07D495/10 |
主分类号 |
C07D471/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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