| 摘要 |
Compound of formula (I): <IMAGE> (I) in which: R1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group, R2 represents an unsubstituted or substituted alkyl group, X1 represents -NH-, X2 represents -O-, R3 represents a hydrogen atom or an alkyl or phenyl group, R4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different, R5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as endothelin convertase inhibitor.
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