发明名称 |
Therapeutic agents for reducing parathyroid hormone levels |
摘要 |
<p>Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X - X - X - X - X - X - X, wherein the X subunit comprises a thiol-containing moiety and the distribution of charge on the X-X subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.</p> |
申请公布号 |
AU2010278897(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
AU20100278897 |
申请日期 |
2010.07.29 |
申请人 |
KAI PHARMACEUTICALS, INC. |
发明人 |
KARIM, FELIX;BARUCH, AMOS;MACLEAN, DEREK;DAS, KANAD;YIN, QUN |
分类号 |
C07K7/06;A61K38/08;A61P3/14;A61P5/00;A61P5/20 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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