| 发明名称 |
METHODS AND REAGENTS FOR EFFICIENT AND TARGETED GENE TRANSFER TO MONOCYTES AND MACROPHAGES |
| 摘要 |
The present invention provides a biosafe and useful vector to transfer genetic material to CD14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells. |
| 申请公布号 |
US2012045389(A1) |
申请公布日期 |
2012.02.23 |
| 申请号 |
US201013266763 |
申请日期 |
2010.04.28 |
| 申请人 |
GASSULL DURO MIQUEL ANGEL;RIO FERNANDEZ ADOLFO;FERNANDEZ GIMENO ESTER;CHILLON RODRIGUEZ MIGUEL;UNIVERSITAT AUTONOMA DE BARCELONA;FUNDACIO PRIVADA INSTITUCIO CATALANA DE RECERCA IESTUDIS AVANCATS;FUNDACIO INSTITUT D'INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL;GRIFOLS, S.A. |
发明人 |
GASSULL DURO MIQUEL ANGEL;RIO FERNANDEZ ADOLFO;FERNANDEZ GIMENO ESTER;CHILLON RODRIGUEZ MIGUEL |
| 分类号 |
A61K39/00;A61K31/70;A61K31/7088;A61K31/713;A61K38/02;A61K48/00;A61K51/08;A61P29/00;A61P35/00;A61P37/02;A61P37/04;B82Y5/00;C12N5/078;C12N5/0784 |
主分类号 |
A61K39/00 |
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