PHARMACEUTICAL COMPOSITIONS OF CARVEDILOL SALTS AND PROCESS FOR PREPARATION THEREOF
摘要
The present invention relates provides pharmaceutical compositions comprising an amorphous carvedilol salt and one or more pharmaceutically acceptable excipients, wherein the amorphous carvedilol salt is formed in situ during the preparation of the pharmaceutical composition. The amorphous carvedilol salt is preferably an amorphous carvedilol phosphate salt. The pharmaceutical compositions can be prepared by providing one or more inert cores; contacting the core or cores with a solution or a dispersion comprising carvedilol, an acid component and optionally a binder, in a solvent; removing the solvent; and optionally coating the core or cores with an extended release composition. Preferred pharmaceutical compositions contain both immediate-release pellets and at least one population of extended-release pellet.
申请公布号
WO2011119477(A3)
申请公布日期
2012.02.23
申请号
WO2011US29178
申请日期
2011.03.21
申请人
AMNEAL PHARMACEUTICALS, LLC;DESAI, JATIN;GAJJAR, VIPUL RASIKBHAI;MISTRY, GAURAV NAVINBHAI;PUROHIT, PARVA YOGESHCHANDRA
发明人
DESAI, JATIN;GAJJAR, VIPUL RASIKBHAI;MISTRY, GAURAV NAVINBHAI;PUROHIT, PARVA YOGESHCHANDRA